克罗米酚对男性低促性腺素强迫症减退症有效

纽约（路透社健康版）1月底四日美联社：据发表在12月底出版的《受孕与不育》杂志的一项通报指出克罗米胺对部分更高促性腺素高血压减退的成年病变稳固。来自阿伯丁肯塔基的大学的该通报的第一作者Scott J. Whitten耶鲁大学在不能接受路透通讯社采访话知道：“原发性或获得性HH病变在不能接受侵害性更大和更为昂贵的治疗（例如注射促性腺激素类）前开展4个月底的克罗米胺试验性治疗是稳固的。”Whitten耶鲁大学和同事研究者了克罗米胺对10名HH成年病变（HH是导致成年不育的少见各种因素）是否有效。通报称克罗米胺治疗1年后，4名卡尔曼(氏)综合征病变中只有一名病变的精子浓度减低而全肾上腺功能减退症病变的精子缺乏病因均没有获取有所改善。显然，该通报指出3名成年胃癌的原发性HH成年病变经过3个月底克罗米胺的治疗精子浓度有了明显减低。近期该组病变已有两名回复了受孕能力。Whitten耶鲁大学知道：“除非对克罗米胺治疗没有反应，我们一定会因为副作用停止对病变使用该类固醇。”最后作者总结知道：“因为条件有限，对HH病变促性腺激素类类固醇和克罗米胺的随机研究者难以开展，然而利用多系列的严格自由选择标准对病变开展分级可能协助全面性验证克罗米胺回复成年更高受孕能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编者：深蓝色幻想

编者： 张靖